A central role for ROS in the functional remodelling of L-type Ca channels by hypoxia
نویسندگان
چکیده
One con health a *Autho School of Medicine, University of Leeds, Worsley Building, Leeds LS2 9JT, UK Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, UK Department of Neurobiology & Behavior, University of California, Irvine, CA 92697-4550, USA Department of Pharmacology, University of Alberta, Edmonton, Alta., Canada Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA School of Biological Sciences, University of Leeds, LS2 9JT Leeds, UK
منابع مشابه
Pii: S0304-3940(01)02479-x
Arterial and airway chemoreceptors respond to acute hypoxia by depolarizing, thereby activating voltage-gated Ca channels and so permitting Ca entry to trigger transmitter release. Following periods of prolonged hypoxia, these cells undergo a form of remodelling which involves altered expression of ion channels. Here, we use microspectrofluorimetric recordings of voltage-gated Ca entry (activat...
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تاریخ انتشار 2008